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The circadian clock of Drosophila and its implication in the regulation of activity and sleep
The circadian clock in the brain controls the timing of behaviour including the timing of the sleep-wake cycle. The clock consists of a network of clock neurons that all generate circadian molecular oscillations but have different neuronal properties (they express different transmitters, show different projections and connections...). This general clock organization is preserved in all animals. The fruit fly Drosophila melanogaster has the advantage that the clock contains fewer neurons and that these can be manipulated separately making the fly a perfect model system to explore the function of the clock network in detail. The present talk will give an overview about the role of the fruit fly’s clock neurons in the control of activity and sleep - always making the comparison to mammals.
Ce séminaire est proposé par le laboratoire de Neurobiologie