A team from the Langevin Institute (ESPCI,CNRS, Inserm) led by Mickaël Tanter, Inserm research director at ESPCI, has just passed a crucial step towards super high resolution ultrasound medical imaging. Scientists managed to report on the non invasive in vivo rat brain vascular activity, with a much better resolution than any other existing technique. Far from common ultrasound imaging, the technique was rather inspired by ultra high optical resolution (FPALM) which was awarded with the Nobel Prize for Chemistry in 2014. Their work was published in the prestigious journal Nature and constitutes an important breakthrough for biomedical imaging. It is the first microscopic imaging technique allowing to see deep into living tissues. Potential applications are numerous, from the early detection of cancer tumors or other cardiovascular and neurologic pathologies.