DNA origami and how we use it to understand biology
It is widely accepted that the biophysical context of ligands and receptors has a significant impact on downstream signaling, however the concept is poorly understood due to difficulties in controlling and analyzing the microenvironment on the nanoscale. I will talk about how we think that DNA-nanotechnology can be of great help in both learning the tactile alphabet of cells by stimulation using protein decorated DNA-origami ’nano-calipers’ and of help in understanding the binding of antibodies. I will also briefly present our recent work on ’3D-printing’ DNA origami wireframe structures.