Björn Högberg (Karolinska Institutet)

30 septembre 11:30 » 12:30 — Bibliothèque PCT - F3.04

DNA origami and how we use it to understand biology

It is widely accepted that the biophysical context of ligands and receptors has a significant impact on downstream signaling, however the concept is poorly understood due to difficulties in controlling and analyzing the microenvironment on the nanoscale. I will talk about how we think that DNA-nanotechnology can be of great help in both learning the tactile alphabet of cells by stimulation using protein decorated DNA-origami ’nano-calipers’ and of help in understanding the binding of antibodies. I will also briefly present our recent work on ’3D-printing’ DNA origami wireframe structures.

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