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ESPCI Paris
ESPCI Paris is a major institution of higher education (a French "Grande École d’ingénieurs"), an internationally renowned research center (6 Nobel Prizes), and a fertile ground of innovation for industry (3 start-ups created/year). ESPCI is a highly multidisciplinary environment with teaching and research in physics, chemistry and biology.
Prof. Andrew Griffiths’ Lab
The research activities of the Laboratory of Biochemistry at ESPCI Paris, directed by Prof. Andrew GRIFFITHS, are based around droplet-based microfluidics, a powerful new ultrahigh-throughput system in which reaction volumes can be miniaturized by up to a million-fold compared to conventional assays in microtitre plates. This opens up exciting prospects for the development of extremely innovative systems with many applications in the Life Sciences. The successful candidate will join a highly multidisciplinary team, with experience spanning biology, chemistry and physics.
Project
The throughput of droplet microfluidics coupled to next generation sequencing allows to screen exhaustively up to millions of point mutants of an enzyme for catalytic activity. Our goal is to harness the massive datasets generated by this experimental approach to understand the relation between enzyme sequence and function, with potential applications in enzyme engineering and optimization.
The Post-Doc will work screen libraries of enzyme mutants to map mutational effects using droplet-based microfluidic platform, next generation sequencing, data analysis and modeling.
Requirements
We are seeking a highly motivated Post-Doc with strong experience in droplet microfluidics, molecular biology, data analysis and statistical modeling.
Flexibility, autonomy, the ability to work in a highly multidisciplinary team and good interpersonal skills are essential.
Duration : 3 months renewable
Address your applications (CV + cover letter) by email to :
Prof. Andrew GRIFFITHS
ESPCI Paris - Laboratory of Biochemistry
10 Rue Vauquelin
75005 Paris
job-lbc@espci.fr